Simultaneous quantification of Racemethionine and Taurine in Capsules by HPTLC method was developed and validated. The method was based on separation of drugs followed by post chromatographic derivatization with Ninhydrine and densitometric measurement of their spots at 500 nm. The chromatograms were developed using a mobile phase of n - butanol: acetic acid: water (6:2:2, v/v/v) on pre-coated plate of silica gel GF245 aluminum TLC plate. The Rf values for Racemethionine and Taurine were found to be 0.49 ± 0.03 and 0.34 ± 0.03 respectively. The calibration curves were linear in range of 160 – 560 ng/band and 400 - 1400 ng/band for Racemethionine and Taurine respectively. The % recoveries for Racemethionine and Taurine were found to be in the range of 99.05-100.52 and 98.07-99.48 respectively.
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